Review





Similar Products

ccrf cem human thymoma cells  (ATCC)
96
ATCC ccrf cem human thymoma cells
Ccrf Cem Human Thymoma Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccrf cem human thymoma cells/product/ATCC
Average 96 stars, based on 1 article reviews
ccrf cem human thymoma cells - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
fromamerican type culture collection  (ATCC)
96
ATCC fromamerican type culture collection
Fromamerican Type Culture Collection, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fromamerican type culture collection/product/ATCC
Average 96 stars, based on 1 article reviews
fromamerican type culture collection - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
jurkat  (ATCC)
96
ATCC jurkat
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Jurkat, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jurkat/product/ATCC
Average 96 stars, based on 1 article reviews
jurkat - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
ccrf cem cells  (ATCC)
96
ATCC ccrf cem cells
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Ccrf Cem Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccrf cem cells/product/ATCC
Average 96 stars, based on 1 article reviews
ccrf cem cells - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
1573 hela atcc cat  (ATCC)
95
ATCC 1573 hela atcc cat
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
1573 Hela Atcc Cat, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/1573 hela atcc cat/product/ATCC
Average 95 stars, based on 1 article reviews
1573 hela atcc cat - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
ccl 119 molt 4 atcc cat  (ATCC)
96
ATCC ccl 119 molt 4 atcc cat
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Ccl 119 Molt 4 Atcc Cat, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccl 119 molt 4 atcc cat/product/ATCC
Average 96 stars, based on 1 article reviews
ccl 119 molt 4 atcc cat - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
ccl  (ATCC)
96
ATCC ccl
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Ccl, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccl/product/ATCC
Average 96 stars, based on 1 article reviews
ccl - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
ccrf cem  (ATCC)
96
ATCC ccrf cem
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Ccrf Cem, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccrf cem/product/ATCC
Average 96 stars, based on 1 article reviews
ccrf cem - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
ccrf cem t cells  (ATCC)
96
ATCC ccrf cem t cells
Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) <t>Jurkat</t> and ( C <t>)</t> <t>CEM</t> cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.
Ccrf Cem T Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/ccrf cem t cells/product/ATCC
Average 96 stars, based on 1 article reviews
ccrf cem t cells - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier

Image Search Results


Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) Jurkat and ( C ) CEM cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.

Journal: Oncology Research

Article Title: Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways

doi: 10.32604/or.2026.074945

Figure Lengend Snippet: Gene expression analysis induced by P3C.1 and P3C.2 in three different cell lines. ( A ) Heatmap of differentially expressed genes of MDA-MB-231, ( B ) Jurkat and ( C ) CEM cells treated with P3C.1 and P3C.2, or with solvent control (DMSO). Each column represents the expression values of the different treatments performed for 6 h for each corresponding cell line, and each row denotes data from one transcript. The color legend of each expression values (log2 fold change) is displayed on the right. ( D ) Differentially expressed genes; up-regulated (green bars) and down-regulated (red bars) obtained for each cell line and treatments, considering only transcripts with a log2 fold change of >1.0, and a p -adjusted value of <0.05.

Article Snippet: In addition, the RAMOS (ATCC, CRL-1596), CEM (ATCC, CCL-119), JURKAT (ATCC, TIB-152), NALM-6 (ATCC, CRL-3273), RPMI-8226, MM.1S, MM.1R, U266, Rec-1, JVM-13, A549 (ATCC, CRM-CCL-185), HCC70 (ATCC, CRL-2315), HCC1419 (ATCC, CRL-2326), T47D (ATCC, CRL-2865), KMS-11, and OVCAR-5 cell lines were grown in Roswell Park Memorial Institute-1640 (RPMI-1640) culture media (Cytiva-Hyclone, SH30027FS, UT, USA,) supplemented with 10% FBS, 100 U/mL of penicillin, and 100 μg/mL of streptomycin.

Techniques: Gene Expression, Solvent, Control, Expressing

P3C.1 and P3C.2 differentially expressed genes induced in common. ( A ) MDA-MB-231, ( B ) Jurkat, and CEM common DEGs identified for both compounds. ( C ) P3C.1 and P3C.2 induced 4 up-regulated genes in common (DUSP8, KLF6, KLF7 and BACH2) in MDA-MB-231, Jurkat and CEM cell lines.

Journal: Oncology Research

Article Title: Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways

doi: 10.32604/or.2026.074945

Figure Lengend Snippet: P3C.1 and P3C.2 differentially expressed genes induced in common. ( A ) MDA-MB-231, ( B ) Jurkat, and CEM common DEGs identified for both compounds. ( C ) P3C.1 and P3C.2 induced 4 up-regulated genes in common (DUSP8, KLF6, KLF7 and BACH2) in MDA-MB-231, Jurkat and CEM cell lines.

Article Snippet: In addition, the RAMOS (ATCC, CRL-1596), CEM (ATCC, CCL-119), JURKAT (ATCC, TIB-152), NALM-6 (ATCC, CRL-3273), RPMI-8226, MM.1S, MM.1R, U266, Rec-1, JVM-13, A549 (ATCC, CRM-CCL-185), HCC70 (ATCC, CRL-2315), HCC1419 (ATCC, CRL-2326), T47D (ATCC, CRL-2865), KMS-11, and OVCAR-5 cell lines were grown in Roswell Park Memorial Institute-1640 (RPMI-1640) culture media (Cytiva-Hyclone, SH30027FS, UT, USA,) supplemented with 10% FBS, 100 U/mL of penicillin, and 100 μg/mL of streptomycin.

Techniques:

Ingenuity pathways analysis of genes commonly found in P3C.1 and P3C.2-treated MDA-MB231, JURKAT, and CEM cells, identified canonical pathways implicating these genes in kinase-mediated signal transduction (see green asterisks * ), including RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Protein Kinase A Signaling, and the SAPK/JNK signaling pathway, as well as cell signaling processes (see blue asterisks * ), and membrane dynamics (see blue asterisks * ). The figure shown was recreated from the original IPA histogram to enlarge features and improve legibility.

Journal: Oncology Research

Article Title: Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways

doi: 10.32604/or.2026.074945

Figure Lengend Snippet: Ingenuity pathways analysis of genes commonly found in P3C.1 and P3C.2-treated MDA-MB231, JURKAT, and CEM cells, identified canonical pathways implicating these genes in kinase-mediated signal transduction (see green asterisks * ), including RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Protein Kinase A Signaling, and the SAPK/JNK signaling pathway, as well as cell signaling processes (see blue asterisks * ), and membrane dynamics (see blue asterisks * ). The figure shown was recreated from the original IPA histogram to enlarge features and improve legibility.

Article Snippet: In addition, the RAMOS (ATCC, CRL-1596), CEM (ATCC, CCL-119), JURKAT (ATCC, TIB-152), NALM-6 (ATCC, CRL-3273), RPMI-8226, MM.1S, MM.1R, U266, Rec-1, JVM-13, A549 (ATCC, CRM-CCL-185), HCC70 (ATCC, CRL-2315), HCC1419 (ATCC, CRL-2326), T47D (ATCC, CRL-2865), KMS-11, and OVCAR-5 cell lines were grown in Roswell Park Memorial Institute-1640 (RPMI-1640) culture media (Cytiva-Hyclone, SH30027FS, UT, USA,) supplemented with 10% FBS, 100 U/mL of penicillin, and 100 μg/mL of streptomycin.

Techniques: Transduction, Activation Assay, Membrane

Connectivity map analyses revealed strong connectivity of P3C compounds with tubulin inhibitors. The top 20 perturbagens identified using P3C.1 and P3C.2 genes in common for ( A ) MDA-MB-231, and ( B ) Jurkat, and CEM cell lines. Tau scores of 90 or above have been previously recognized as strong and suitable for further investigation ( https://clue.io ).

Journal: Oncology Research

Article Title: Discovery of Two Novel Pyrazole Derivatives as Anticancer Agents Targeting Tubulin Polymerization and MAPK Signaling Pathways

doi: 10.32604/or.2026.074945

Figure Lengend Snippet: Connectivity map analyses revealed strong connectivity of P3C compounds with tubulin inhibitors. The top 20 perturbagens identified using P3C.1 and P3C.2 genes in common for ( A ) MDA-MB-231, and ( B ) Jurkat, and CEM cell lines. Tau scores of 90 or above have been previously recognized as strong and suitable for further investigation ( https://clue.io ).

Article Snippet: In addition, the RAMOS (ATCC, CRL-1596), CEM (ATCC, CCL-119), JURKAT (ATCC, TIB-152), NALM-6 (ATCC, CRL-3273), RPMI-8226, MM.1S, MM.1R, U266, Rec-1, JVM-13, A549 (ATCC, CRM-CCL-185), HCC70 (ATCC, CRL-2315), HCC1419 (ATCC, CRL-2326), T47D (ATCC, CRL-2865), KMS-11, and OVCAR-5 cell lines were grown in Roswell Park Memorial Institute-1640 (RPMI-1640) culture media (Cytiva-Hyclone, SH30027FS, UT, USA,) supplemented with 10% FBS, 100 U/mL of penicillin, and 100 μg/mL of streptomycin.

Techniques: